ProjectsProyectos
Current studies, research areas, and funding of Joseph Friedman, MD, PhD, including Drug Checking San Diego, Chill Packs, and the La Frontera II binational cohort.
Current studiesEstudios actuales
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Chill PacksEvaluating self-administered olanzapine as a psychiatric harm reduction intervention to prevent methamphetamine-induced psychosis. Funded by a UC San Diego Community Psychiatry Research Center pilot grant.Evaluación de la olanzapina autoadministrada como intervención psiquiátrica de reducción de daños para prevenir la psicosis inducida por metanfetamina. Financiado con una beca piloto del Centro de Investigación en Psiquiatría Comunitaria de UC San Diego.
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Drug Checking San DiegoPublic health surveillance through community-based drug checking in San Diego.Vigilancia de salud pública mediante el análisis comunitario de sustancias en San Diego.
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La Frontera IIA binational cohort study of the intersection of substance use, HIV, and associated comorbidities among people who inject drugs in San Diego. NIDA U01DA063078.Estudio de cohorte binacional sobre la intersección entre el consumo de sustancias, el VIH y comorbilidades asociadas en personas que se inyectan drogas en San Diego. NIDA U01DA063078.
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Research areasÁreas de investigación
Los títulos de los artículos se muestran en su idioma original.
Epidemiology of the US overdose crisisEpidemiología de la crisis de sobredosis en EE. UU.
- Charting the fourth wave: Geographic, temporal, race/ethnicity and demographic trends in polysubstance fentanyl overdose deaths in the United States, 2010–2021Addiction, 2023
- Charting the decline of the fourth wave: US overdose deaths by race, ethnicity and substance involvementAddiction, 2026
- US overdose mortality saw first drop below the Jalal-Burke exponential growth curve in 2024International Journal of Drug Policy, 2026
- Overdose-Related Cardiac Arrests Observed by Emergency Medical Services During the US COVID-19 EpidemicJAMA Psychiatry, 2020
- COVID-19 and the Drug Overdose Crisis: Uncovering the Deadliest Months in the United States, January‒July 2020American Journal of Public Health, 2021
More papersMás artículos (10)
- What does ‘polysubstance’ really mean? Comparing drug-involved deaths in CDC records vs. detailed medical examiner data from Los AngelesInternational Journal of Drug Policy, 2025
- Assessing an ICD-10 code approach for estimating xylazine-involved overdose deaths in the United StatesDrug and Alcohol Dependence, 2025
- Leveraging pooled medical examiner records to surveil complex and emerging patterns of polysubstance use in the United StatesInternational Journal of Drug Policy, 2024
- Looking Back on COVID-19 and the Evolving Drug Overdose Crisis: Updated Trends Through 2022American Journal of Public Health, 2024
- Increases in drug overdose deaths in Norway and the United States during the COVID-19 pandemicScandinavian Journal of Public Health, 2022
- Longitudinal changes in co-involved drugs, comorbidities, and demographics of methamphetamine-related deaths in Los Angeles CountyJournal of Substance Use and Addiction Treatment, 2023
- Rethinking urban-rural designations in public health surveillance of the overdose crisis and crafting an agenda for future monitoringInternational Journal of Drug Policy, 2023
- Commentary on Lim et al.: Mortality database linkages—A critical methodology to understand the structural drivers of the overdose crisisAddiction, 2023
- Sex and Drug Overdose Mortality Trends, 1999-2020—ReplyJAMA Psychiatry, 2022
- Opioid prescription patterns among patients who doctor shop; Implications for providersPLoS ONE, 2020
Racial and ethnic inequalities in overdoseDesigualdades raciales y étnicas en las sobredosis
- Understanding and Addressing Widening Racial Inequalities in Drug OverdoseAmerican Journal of Psychiatry, 2024
- Deaths of despair and Indigenous data genocideThe Lancet, 2023
- Evaluation of Increases in Drug Overdose Mortality Rates in the US by Race and Ethnicity Before and During the COVID-19 PandemicJAMA Psychiatry, 2022
- Trends in Deaths of Despair by Race and Ethnicity From 1999 to 2022JAMA Psychiatry, 2024
- Surging Racial Disparities in the U.S. Overdose CrisisAmerican Journal of Psychiatry, 2022
More papersMás artículos (7)
- Far From a “White Problem”: Responding to the Overdose Crisis as a Racial Justice IssueAmerican Journal of Public Health, 2022
- Growing racial/ethnic disparities in overdose mortality before and during the COVID-19 pandemic in CaliforniaPreventive Medicine, 2021
- Racial/Ethnic, Social, and Geographic Trends in Overdose-Associated Cardiac Arrests Observed by US Emergency Medical Services During the COVID-19 PandemicJAMA Psychiatry, 2021
- Drug overdose mortality rates among non-Hispanic American Indian/Alaska Native individuals, 1999–2022Annals of Epidemiology, 2025
- Extreme vulnerability to overdose mortality: Intersections of detailed race/ethnicity, educational attainment, age, sex, and nativityDrug and Alcohol Dependence, 2025
- US drug overdose mortality rose faster among hispanics than non-hispanics from 2010 to 2021Drug and Alcohol Dependence, 2023
- Assessment of Racial/Ethnic and Income Disparities in the Prescription of Opioids and Other Controlled Medications in CaliforniaJAMA Internal Medicine, 2019
Youth overdose and counterfeit pillsSobredosis en adolescentes y pastillas falsificadas
- Trends in Drug Overdose Deaths Among US Adolescents, January 2010 to June 2021JAMA, 2022
- The Overdose Crisis among U.S. AdolescentsNew England Journal of Medicine, 2024
- The public health risks of counterfeit pillsThe Lancet Public Health, 2025
- Polysubstance-Involved Opioid Overdose Deaths Among US Youths: 2020 to 2023PEDIATRICS, 2025
- Fentanyl, heroin, and methamphetamine-based counterfeit pills sold at tourist-oriented pharmacies in Mexico: An ethnographic and drug checking studyDrug and Alcohol Dependence, 2023
Addiction on the US–Mexico borderAdicciones en la frontera México–Estados Unidos
- The introduction of fentanyl on the US–Mexico border: An ethnographic account triangulated with drug checking data from TijuanaInternational Journal of Drug Policy, 2022
- Fentanyl, heroin, and methamphetamine-based counterfeit pills sold at tourist-oriented pharmacies in Mexico: An ethnographic and drug checking studyDrug and Alcohol Dependence, 2023
- The Detection of Xylazine in Tijuana, Mexico: Triangulating Drug Checking and Clinical Urine Testing DataJournal of Addiction Medicine, 2025
- Illicit Fentanyl Use and Hepatitis C Virus Seroconversion Among People Who Inject Drugs in Tijuana and San Diego: Results From a Binational Cohort StudyClinical Infectious Diseases, 2024
- An Ethnographic Assessment of COVID-19‒Related Changes to the Risk Environment for People Who Use Drugs in Tijuana, MexicoAmerican Journal of Public Health, 2022
More papersMás artículos (12)
- Methadone treatment and associated health and social outcomes after a national manufacturing closure in Mexico: a longitudinal observational cohort study in TijuanaThe Lancet Regional Health - Americas, 2026
- Epidemiological invisibilisation: a man overdoses in TijuanaThe Lancet, 2026
- Managing xylazine-involved overdoses in a community harm reduction setting: lessons from Tijuana, MexicoHarm Reduction Journal, 2025
- Correlates of recent overdose among people who inject drugs in the San Diego/Tijuana border regionDrug and Alcohol Dependence, 2022
- Changes in injecting versus smoking heroin, fentanyl, and methamphetamine among people who inject drugs in San Diego, California, 2020–2023Drug and Alcohol Dependence, 2024
- Deported, homeless, and into the canal: Environmental structural violence in the binational Tijuana RiverSocial Science & Medicine, 2022
- Health risks and cross-border environmental exposure: A binational study of the San Diego-Tijuana-Rosarito Pacific Ocean coastlineEnvironmental Challenges, 2026
- Excess Out-of-Hospital Mortality and Declining Oxygen Saturation: The Sentinel Role of Emergency Medical Services Data in the COVID-19 Crisis in Tijuana, MexicoAnnals of Emergency Medicine, 2020
- Tracking Drug Overdose in Latin America: The Epidemiological Potential of Prehospital and Emergency Department DataAmerican Journal of Public Health, 2024
- Geographical and socioeconomic disparities in opioid access in Mexico, 2015–19: a retrospective analysis of surveillance dataThe Lancet Public Health, 2021
- Potency-Enhancing Synthetics in the Drug Overdose Epidemic: Xylazine (“Tranq”), Fentanyl, Methamphetamine, and the Displacement of Heroin in Philadelphia and TijuanaJournal of Illicit Economies and Development, 2022
- Integrating Data Science and Ethnography for Critically Applied Rapid Surveillance of Emerging Health InequalitiesPhD dissertation, University of California, Los Angeles, 2022
Drug checking and the emerging drug supplyAnálisis de sustancias y el suministro emergente de drogas
- Xylazine Spreads Across the US: A Growing Component of the Increasingly Synthetic and Polysubstance Overdose CrisisDrug and Alcohol Dependence, 2021
- What Dose of Methamphetamine Do Regular Consumers Use Daily? Estimating Oral Amphetamine Milligram EquivalentsJournal of Addiction Medicine, 2026
- Estimating the daily milligrams of morphine equivalent of illicit fentanyl use in Los Angeles: Clinical and epidemiological implicationsDrug and Alcohol Dependence, 2026
- UV Stabilizer BTMPS in the Illicit Fentanyl Supply in 9 US LocationsJAMA, 2025
- Quetiapine: A Novel Additive to the Illicit Heroin Supply in Los AngelesJournal of Addiction Medicine, 2025
More papersMás artículos (7)
- Xylazine prevalence and concentration in the Los Angeles fentanyl market, 2023–2025Drug and Alcohol Dependence Reports, 2025
- High variation in purity of consumer-level illicit fentanyl samples in Los Angeles, September 2023–April 2025International Journal of Drug Policy, 2025
- Crystal Clear: Purity of consumer-level methamphetamine samples and methamphetamine-adulteration of other drugs in Los Angeles, 2023-2025Drug and Alcohol Dependence Reports, 2026
- Assessing the real-world performance of xylazine test strips for community-based drug checking in Los AngelesHarm Reduction Journal, 2026
- The emerging fentanyl–xylazine syndemic in the USA: challenges and future directionsThe Lancet, 2023
- Commentary on Copeland et al.: Does xylazine in the United Kingdom foreshadow a European synthetic polysubstance drug crisis?Addiction, 2024
- Potency-Enhancing Synthetics in the Drug Overdose Epidemic: Xylazine (“Tranq”), Fentanyl, Methamphetamine, and the Displacement of Heroin in Philadelphia and TijuanaJournal of Illicit Economies and Development, 2022
Psychiatry, treatment, and harm reductionPsiquiatría, tratamiento y reducción de daños
- “Chill packs” self-administered olanzapine as psychiatric harm reduction for methamphetamine-induced psychosis: a narrative review of the existing evidence baseHarm Reduction Journal, 2026
- What Dose of Methamphetamine Do Regular Consumers Use Daily? Estimating Oral Amphetamine Milligram EquivalentsJournal of Addiction Medicine, 2026
- Estimating the daily milligrams of morphine equivalent of illicit fentanyl use in Los Angeles: Clinical and epidemiological implicationsDrug and Alcohol Dependence, 2026
- Clinical Characteristics of Emergency Visits Related to Recreational Psychedelic UseCommunity Mental Health Journal, 2026
- Prevalence and Reasons for Microdosing Cannabis, Psilocybin, LSD, and MDMA Among U.S. AdultsAmerican Journal of Preventive Medicine, 2026
More papersMás artículos (9)
- Internet Searches for Lorazepam Following the Release of The White LotusJAMA Health Forum, 2025
- Recovery incentives program: California’s contingency management benefitPreventive Medicine, 2023
- Buprenorphine deregulation as an opioid crisis policy response - A comparative analysis between France and the United StatesInternational Journal of Drug Policy, 2023
- Substance Use Disorder and Harm Reduction Curriculum in United States and Canadian Undergraduate Medical Education: An Online SurveySubstance Use & Addiction Journal, 2025
- Decreasing Stigma Toward People Who Inject Drugs: Harm Reduction Training for First-Year Medical StudentsAcademic Medicine, 2024
- Medical Student–Led Initiative to Incorporate Harm Reduction into Medical School CurriculumAcademic Psychiatry, 2023
- Intersectional structural vulnerability to abusive policing among people who inject drugs: A mixed methods assessment in California’s central valleyInternational Journal of Drug Policy, 2020
- Substance use policy and practice in the COVID-19 pandemic: Learning from early pandemic responses through internationally comparative field dataGlobal Public Health, 2022
- Modeling the impact of changing drug markets and structural determinants on HCV and/or HIV transmission among people who inject drugs in the United States: A rural and urban comparisonInternational Journal of Drug Policy, 2025
Global health metrics and health inequalityMétricas de salud global y desigualdad en salud
- Measuring and forecasting progress towards the education-related SDG targetsNature, 2020
- Quantifying the effects of the COVID-19 pandemic on gender equality on health, social, and economic indicators: a comprehensive review of data from March, 2020, to September, 2021The Lancet, 2022
- Predictive performance of international COVID-19 mortality forecasting modelsNature Communications, 2021
- International COVID-19 mortality forecast visualization: covidcompare.ioJAMIA Open, 2021
- Inequalities in COVID-19 mortality: defining a global research agendaBulletin of the World Health Organization, 2022
More papersMás artículos (24)
- COVID-19 and the Nordic Paradox: a call to measure the inequality reducing benefits of welfare systems in the wake of the pandemicSocial Science & Medicine, 2021
- The radically unequal distribution of Covid-19 vaccinations: a predictable yet avoidable symptom of the fundamental causes of inequalityHumanities and Social Sciences Communications, 2022
- U.S. Children “Learning Online” during COVID-19 without the Internet or a Computer: Visualizing the Gradient by Race/Ethnicity and Parental Educational AttainmentSocius Sociological Research for a Dynamic World, 2021
- Mapping local variation in educational attainment across AfricaNature, 2018
- Improving the estimation of educational attainment: New methods for assessing average years of schooling from binned dataPLoS ONE, 2018
- Parental education and inequalities in child mortality: a global systematic review and meta-analysisThe Lancet, 2021
- Effects of education on adult mortality: a global systematic review and meta-analysisThe Lancet Public Health, 2024
- Measuring human capital: a systematic analysis of 195 countries and territories, 1990–2016The Lancet, 2018
- Forecasting life expectancy, years of life lost, and all-cause and cause-specific mortality for 250 causes of death: reference and alternative scenarios for 2016–40 for 195 countries and territoriesThe Lancet, 2018
- Measuring progress and projecting attainment on the basis of past trends of the health-related Sustainable Development Goals in 188 countries: an analysis from the Global Burden of Disease Study 2016The Lancet, 2017
- Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970–2016: a systematic analysis for the Global Burden of Disease Study 2016The Lancet, 2017
- Global, regional, national, and selected subnational levels of stillbirths, neonatal, infant, and under-5 mortality, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015The Lancet, 2016
- Global, regional, and national levels of maternal mortality, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015The Lancet, 2016
- Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015The Lancet, 2016
- Estimates of global, regional, and national incidence, prevalence, and mortality of HIV, 1980–2015: the Global Burden of Disease Study 2015The Lancet HIV, 2016
- Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021The Lancet, 2024
- Global age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950–2021, and the impact of the COVID-19 pandemic: a comprehensive demographic analysis for the Global Burden of Disease Study 2021The Lancet, 2024
- The evolution of serious health-related suffering from 1990 to 2021: an update to The Lancet Commission on global access to palliative care and pain reliefThe Lancet Global Health, 2025
- Global Assessment of Palliative Care Need: Serious Health-Related Suffering Measurement MethodologyJournal of Pain and Symptom Management, 2024
- Structural vulnerability to narcotics-driven firearm violence: An ethnographic and epidemiological study of Philadelphia’s Puerto Rican inner-cityPLoS ONE, 2019
- Quantifying disparities in access to public-sector abortion based on legislative differences within the Mexico City Metropolitan AreaContraception, 2018
- Accompaniment on the edge: What can the US learn from Latin America about contested abortion care?PLOS Global Public Health, 2023
- Pursuing Global Equity in Access to Cancer DrugsJAMA Oncology, 2019
- Novel metrics to measure gender bias in operating room scheduling priorityAmerican Journal of Obstetrics and Gynecology, 2024
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FundingFinanciamiento
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A binational cohort of the intersection between substance use, HIV, and associated comorbidities among people who inject drugs in San DiegoCohorte binacional sobre la intersección entre el consumo de sustancias, el VIH y comorbilidades asociadas en personas que se inyectan drogas en San Diego
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‘Chill Packs’: evaluating self-administered olanzapine as a psychiatric harm reduction intervention to prevent methamphetamine-induced psychosis‘Chill Packs’: evaluación de la olanzapina autoadministrada como intervención psiquiátrica de reducción de daños para prevenir la psicosis inducida por metanfetamina
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Employing fentanyl test strips in community harm reduction settings in Tijuana, MexicoUso de tiras reactivas de fentanilo en espacios comunitarios de reducción de daños en Tijuana, México
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Assessing fentanyl and HIV among people who inject drugs in Tijuana, MexicoEvaluación del fentanilo y el VIH en personas que se inyectan drogas en Tijuana, México
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National Institute of General Medical Sciences, T32 GM008042
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Data toolsHerramientas de datos
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Drug Checking San Diego results lookupConsulta de resultados de Drug Checking San DiegoLets people who submit a sample to Drug Checking San Diego look up its lab results with their RaDAR ID. Also embedded on the Data page.Permite a quienes entregan una muestra a Drug Checking San Diego consultar sus resultados de laboratorio con su identificador RaDAR. También aparece en la página de Datos.
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Drug Checking Los Angeles results dashboardPanel de resultados de Drug Checking Los AngelesIndividual sample results, summary statistics, and technical notes for Drug Checking Los Angeles. Also embedded on the Data page.Resultados de muestras individuales, estadísticas resumidas y notas técnicas de Drug Checking Los Angeles. También aparece en la página de Datos.
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covidcompare.ioA platform comparing the predictive performance of international COVID-19 mortality forecasting models.Plataforma que compara el desempeño predictivo de los modelos internacionales de pronóstico de mortalidad por COVID-19.
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